The International Interdisciplinary Network on Smart Healthy Age-Friendly Environments (NET4Age-Friendly) is focused on creating inclusive and supportive environments through smart and inclusive design, digital innovations, and integrated healthcare pathways. This Reference Framework outlines the key resources, structures, practices, guidelines, and standards essential for achieving these objectives. It serves as a comprehensive guide for researchers, policymakers, and practitioners working to improve the quality of life of people throughout the life course, ensuring that innovations in social, digital, and healthcare sectors are inclusive, sustainable, and accessible.